MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Acinetobacter radioresistens SK82

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Reactions and Genes L-Serine (N)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
MPMX26_01477 N.D.
MPMX26_01673 -0.9
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
MPMX26_02810 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
MPMX26_01371 N.D.
MPMX26_01680 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
MPMX26_02748 -3.9
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
MPMX26_02811 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
MPMX26_02020 -3.4
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
MPMX26_01340 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
MPMX26_02021 -4.2
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
MPMX26_02020 -3.4
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
MPMX26_00855 N.D.
MPMX26_01459 N.D.
MPMX26_01473 +0.1
MPMX26_01871 -4.9
MPMX26_02146 -5.1
MPMX26_02586 -4.7
MPMX26_02954 -0.8
MPMX26_02978 -0.1
MPMX26_03000 -1.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information