MetaCyc Pathway: (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) in Acinetobacter radioresistens SK82

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Reactions and Genes L-tyrosine (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
MPMX26_00225 -0.3
MPMX26_00611 N.D.
MPMX26_00837 N.D.
MPMX26_01592 N.D.
MPMX26_01701 -1.0
MPMX26_01750 +0.0
MPMX26_02383 -0.9
MPMX26_02495 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
MPMX26_00226 -0.6
MPMX26_00610 +0.6
MPMX26_01177 N.D.
MPMX26_03059 -1.7
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
MPMX26_00951 N.D.
(S)-3-hydroxybutanoyl-CoA + H2O→(S)-3-hydroxybutanoate + coenzyme A + H+
MPMX26_02729 -5.3
(3R)-3-hydroxybutanoyl-CoA + H2O→(R)-3-hydroxybutanoate + coenzyme A + H+
MPMX26_02729 -5.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information