MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Escherichia coli BW25113

Reactions and Genes	Putrescine (N)
Arginine decarboxylase: L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
b2938 (speA)	-0.1
b4117 (adiA)	-0.0
Agmatinase: agmatine + H2O→putrescine + urea (EC 3.5.3.11)
b2937 (speB)	-0.0
Putrescine aminotransferase: putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
b3073 (ygjG)	-0.9
Glutamate--putrescine ligase: putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
b1297 (b1297)	-4.9
Aminobutyraldehyde dehydrogenase: 4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
b1300 (puuC)	-5.0
b1444 (ydcW)	-0.5
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
b1301 (puuB)	-6.9
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
b1300 (puuC)	-5.0
Gamma-glutamyl-gamma-aminobutyrate hydrolase: 4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
b1298 (ycjL)	-5.3
4-aminobutyrate transaminase: 4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
b1302 (puuE)	-0.3
b2662 (gabT)	-0.4
Succinate-semialdehyde dehydrogenase: succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
b1300 (puuC)	-5.0
b1525 (b1525)	-0.4
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
b2661 (gabD)	+0.2

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information