MetaCyc Pathway: L-tyrosine degradation I in Variovorax sp. OAS795

Reactions and Genes	L-Phenylalanine (C)
	remove
Aspartate transaminase: L-tyrosine + 2-oxoglutarate→3-(4-hydroxyphenyl)pyruvate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
ABID97_RS04080	+0.2
ABID97_RS05635	-0.2
ABID97_RS06550	+0.2
ABID97_RS08770	+0.2
ABID97_RS10885	-4.7
ABID97_RS13335	+0.2
ABID97_RS13990	-3.6
ABID97_RS16605	-0.1
ABID97_RS17310	-6.3
ABID97_RS17960	-0.2
ABID97_RS18035	+0.1
ABID97_RS20530	+0.2
ABID97_RS21960	-0.2
ABID97_RS23145	-0.1
ABID97_RS24840	-0.1
ABID97_RS27360	+0.0
ABID97_RS27595	-0.2
ABID97_RS27655	+0.0
4-hydroxyphenylpyruvate dioxygenase: 3-(4-hydroxyphenyl)pyruvate + dioxygen→homogentisate + CO₂ (EC 1.13.11.27)
ABID97_RS19690	+0.0
ABID97_RS25360	-6.5
Homogentisate 1,2-dioxygenase: homogentisate + dioxygen→4-maleyl-acetoacetate + H⁺ (EC 1.13.11.5)
ABID97_RS03960	-2.5
ABID97_RS29490	-0.2
Maleylacetoacetate isomerase: 4-maleyl-acetoacetate→4-fumaryl-acetoacetate (EC 5.2.1.2)
ABID97_RS12400	-5.3
Fumarylacetoacetase: 4-fumaryl-acetoacetate + H₂O→acetoacetate + fumarate + H⁺ (EC 3.7.1.2)
ABID97_RS03145	+0.1
ABID97_RS03955	-7.0
ABID97_RS04260	+0.0
ABID97_RS12395	-0.5
ABID97_RS13435	-0.2
ABID97_RS20690	+0.2
ABID97_RS29500	-0.2

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Pathway details at MetaCyc
Fitness data for 30 genes
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All MetaCyc pathways for Variovorax sp. OAS795

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information