MetaCyc Pathway: 2-methylcitrate cycle I in Pseudomonas putida KT2440

Add experiment(s):


Reactions and Genes Acetate Carbon Source (20mM)
remove
Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
PP_2351 +0.0
PP_4487 -4.8
PP_4702 +0.1
2-methylcitrate synthase:
propanoyl-CoA + oxaloacetate + H2O→(2S,3S)-2-methylcitrate + coenzyme A + H+ (EC 2.3.3.5)
PP_2335 -0.2
2-methylcitrate dehydratase:
(2S,3S)-2-methylcitrate→cis-2-methylaconitate + H2O (EC 4.2.1.79)
PP_2336 +0.0
PP_2338 -0.1
2-methylisocitrate dehydratase (in reverse):
cis-2-methylaconitate + H2O→(2R,3S)-2-methylisocitrate (EC 4.2.1.99)
PP_2336 +0.0
PP_2339 N.D.
Methylisocitrate lyase:
(2R,3S)-2-methylisocitrate→pyruvate + succinate (EC 4.1.3.30)
PP_2334 +0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information