MetaCyc Pathway: superpathway of N-acetylneuraminate degradation in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

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Reactions and Genes LB_plus_SM_buffer with FelixO1_phage 0.05 MOI
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N-acetyl-β-neuraminate→aceneuramate (EC 5.1.3.24)
GFF2961 -0.6
N-acetylneuraminate lyase:
aceneuramate→N-acetyl-D-mannosamine + pyruvate (EC 4.1.3.3)
GFF2965 +0.1
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
GFF2962 -0.2
N-acylglucosamine-6-phosphate 2-epimerase:
N-acetyl-D-mannosamine 6-phosphate→N-acetyl-D-glucosamine 6-phosphate (EC 5.1.3.9)
GFF2963 -0.2
GFF3307 +0.1
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25)
GFF4585 +2.0
Glucosamine-6-phosphate deaminase:
D-glucosamine 6-phosphate + H2O→β-D-fructofuranose 6-phosphate + ammonium (EC 3.5.99.6)
GFF4586 -4.3
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
GFF2283 +1.0
GFF3516 -0.1
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
GFF3020 N.D.
GFF314 +0.0
GFF3839 +0.0
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
GFF2306 +0.1
GFF660 -0.2
GFF880 -6.3
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
GFF3478 N.D.
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
GFF2302 N.D.
GFF902 +0.2
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
GFF3021 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
GFF1063 +1.4
GFF398 -0.3
GFF648 +0.7
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
GFF648 +0.7
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
GFF4832 N.D.
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
GFF3539 -0.5
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
GFF1633 +1.5
GFF3567 +3.3
GFF3582 -0.1
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
GFF2101 N.D.
GFF2337 +0.1
GFF2338 -0.1
GFF3207 +0.4
GFF3656 +0.2
GFF3660 +0.3
GFF722 +0.2
GFF723 +0.2
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
GFF2078 -0.5
GFF2749 -0.5
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
GFF1901 +3.3
GFF2081 +0.1
GFF3938 +0.0
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
GFF1628 -0.0
GFF1900 +3.2
GFF2083 -0.4
GFF2084 N.D.
GFF3208 +0.4
GFF3928 -0.1
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
GFF2132 -0.3
GFF2262 -0.4
GFF2557 -0.0
GFF2617 +0.1
GFF2749 -0.5
GFF957 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information