MetaCyc Pathway: TCA cycle I (prokaryotic) in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

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Reactions and Genes LB_plus_SM_buffer with FelixO1_phage 0.5 MOI
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2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
GFF120 N.D.
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
GFF4641 -3.1
GFF4642 -1.2
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
GFF10 N.D.
GFF1477 +0.1
GFF1806 +0.9
GFF1807 +0.9
GFF3577 +0.2
GFF9 N.D.
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
GFF2149 -1.3
GFF2556 +1.4
GFF3033 +0.3
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
GFF4634 -1.8
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
GFF115 -1.2
GFF2709 +0.1
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
GFF115 -1.2
GFF2709 +0.1
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
GFF3422 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information