MetaCyc Pathway: reductive TCA cycle II in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

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Reactions and Genes LB_plus_SM_buffer with FelixO1_phage 0.5 MOI
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2-oxoglutarate synthase (in reverse):
succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
2-oxoglutarate carboxylase:
2-oxoglutarate + ATP + CO2 + H2O→oxalosuccinate + ADP + 2 H+ + phosphate (EC 6.4.1.7)
No genes
oxalosuccinate + NADH + H+→D-threo-isocitrate + NAD+
No genes
Aconitate hydratase (in reverse):
D-threo-isocitrate→cis-aconitate + H2O (EC 4.2.1.3)
GFF115 -1.2
GFF2709 +0.1
Aconitate hydratase (in reverse):
cis-aconitate + H2O→citrate (EC 4.2.1.3)
GFF115 -1.2
GFF2709 +0.1
Citrate--CoA ligase:
citrate + ATP + coenzyme A→(3S)-citryl-CoA + ADP + phosphate (EC 6.2.1.18)
No genes
Citryl-CoA lyase:
(3S)-citryl-CoA→acetyl-CoA + oxaloacetate (EC 4.1.3.34)
GFF220 -0.3
GFF3075 +0.3
GFF4528 +0.3
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
GFF2149 -1.3
GFF2556 +1.4
GFF3033 +0.3
Pyruvate synthase (in reverse):
acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
GFF2642 -0.0
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
GFF10 N.D.
GFF1477 +0.1
GFF1806 +0.9
GFF1807 +0.9
GFF3577 +0.2
GFF9 N.D.
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
GFF1996 +0.0
GFF1997 -0.5
GFF1998 -0.1
GFF1999 -0.0
Succinate--CoA ligase (ADP-forming):
succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5)
GFF4641 -3.1
GFF4642 -1.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information