MetaCyc Pathway: reductive TCA cycle I in Variovorax sp. OAS795

Reactions and Genes	L-Histidine (C)
2-oxoglutarate synthase (in reverse): succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
ABID97_RS28055	+0.0
ABID97_RS28060	-0.0
Isocitrate dehydrogenase (NADP(+)) (in reverse): 2-oxoglutarate + CO2 + NADPH→D-threo-isocitrate + NADP+ (EC 1.1.1.42)
ABID97_RS16920	-1.1
Aconitate hydratase (in reverse): D-threo-isocitrate→cis-aconitate + H2O (EC 4.2.1.3)
ABID97_RS08535	N.D.
ABID97_RS08550	+3.6
Aconitate hydratase (in reverse): cis-aconitate + H2O→citrate (EC 4.2.1.3)
ABID97_RS08535	N.D.
ABID97_RS08550	+3.6
ATP citrate synthase (in reverse): citrate + ATP + coenzyme A→acetyl-CoA + oxaloacetate + ADP + phosphate (EC 2.3.3.8)
No genes
Pyruvate synthase (in reverse): acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Pyruvate carboxylase: pyruvate + ATP + hydrogen carbonate→oxaloacetate + ADP + H+ + phosphate (EC 6.4.1.1)
ABID97_RS01240	+0.1
Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
ABID97_RS05795	+0.0
ABID97_RS08515	N.D.
ABID97_RS17295	+0.0
Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2)
ABID97_RS17545	+2.2
ABID97_RS17550	-0.6
Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
No genes
Succinate--CoA ligase (ADP-forming): succinate + ATP + coenzyme A→succinyl-CoA + ADP + phosphate (EC 6.2.1.5)
ABID97_RS02240	N.D.
ABID97_RS02245	N.D.
ABID97_RS24470	-0.4
ABID97_RS24475	+0.4

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information