MetaCyc Pathway: valproate β-oxidation in Variovorax sp. OAS795

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Reactions and Genes Tween 20 (C)
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
ABID97_RS00815 +0.2
ABID97_RS01435 +0.2
ABID97_RS02880 +0.1
ABID97_RS03115 -0.7
ABID97_RS04670 +0.5
ABID97_RS05865 -1.4
ABID97_RS05900 -0.0
ABID97_RS05990 +0.2
ABID97_RS06010 -0.1
ABID97_RS07755 +0.0
ABID97_RS10620 N.D.
ABID97_RS14445 -0.3
ABID97_RS15740 -0.8
ABID97_RS17005 -0.3
ABID97_RS17010 +0.1
ABID97_RS17470 -0.5
ABID97_RS18490 +0.0
ABID97_RS18595 N.D.
ABID97_RS18600 +0.0
ABID97_RS18605 N.D.
ABID97_RS18635 -0.6
ABID97_RS19410 -0.1
ABID97_RS20990 -0.2
ABID97_RS22770 +0.3
ABID97_RS24015 +0.5
ABID97_RS24805 -0.4
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 -0.8
ABID97_RS27555 -0.1
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS03030 -0.1
ABID97_RS05865 -1.4
ABID97_RS06010 -0.1
ABID97_RS08805 +0.1
ABID97_RS10560 -0.3
ABID97_RS15740 -0.8
ABID97_RS17005 -0.3
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
ABID97_RS04675 +0.0
ABID97_RS05875 N.D.
ABID97_RS06005 -0.1
ABID97_RS10975 -0.1
ABID97_RS11335 -0.1
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 +0.1
ABID97_RS18615 -0.3
ABID97_RS18775 +0.1
ABID97_RS20240 +0.0
ABID97_RS24190 +0.4
ABID97_RS25195 -0.4
ABID97_RS26575 N.D.
ABID97_RS27835 -0.0
ABID97_RS28230 +0.8
ABID97_RS28270 -0.1
ABID97_RS28430 +0.2
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
No genes
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS03030 -0.1
ABID97_RS05865 -1.4
ABID97_RS06010 -0.1
ABID97_RS08805 +0.1
ABID97_RS10560 -0.3
ABID97_RS15740 -0.8
ABID97_RS17005 -0.3
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 +0.0
ABID97_RS05875 N.D.
ABID97_RS06005 -0.1
ABID97_RS10975 -0.1
ABID97_RS11335 -0.1
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 +0.1
ABID97_RS18615 -0.3
ABID97_RS18775 +0.1
ABID97_RS20240 +0.0
ABID97_RS24190 +0.4
ABID97_RS25195 -0.4
ABID97_RS26575 N.D.
ABID97_RS27835 -0.0
ABID97_RS28230 +0.8
ABID97_RS28270 -0.1
ABID97_RS28430 +0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information