MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Variovorax sp. OAS795

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Reactions and Genes Tween 20 (C)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
ABID97_RS06345 -3.9
ABID97_RS28150 -0.0
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
ABID97_RS23255 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
ABID97_RS10255 N.D.
ABID97_RS20195 N.D.
ABID97_RS26060 N.D.
ABID97_RS28005 +0.1
ABID97_RS28010 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
ABID97_RS06300 N.D.
ABID97_RS11220 N.D.
ABID97_RS19715 -0.6
ABID97_RS19720 +0.1
ABID97_RS28755 +0.1
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
ABID97_RS03110 -1.8
ABID97_RS23260 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
ABID97_RS09505 N.D.
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
ABID97_RS19805 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
ABID97_RS09515 N.D.
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
ABID97_RS09510 N.D.
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
ABID97_RS04080 -0.2
ABID97_RS05635 +0.1
ABID97_RS06550 -0.0
ABID97_RS08770 +0.1
ABID97_RS10885 -4.7
ABID97_RS13335 +0.3
ABID97_RS13990 -3.3
ABID97_RS16605 +0.0
ABID97_RS17310 -1.3
ABID97_RS17960 +0.1
ABID97_RS18035 +0.0
ABID97_RS20530 -0.1
ABID97_RS21960 +0.6
ABID97_RS23145 -1.3
ABID97_RS24840 +0.1
ABID97_RS27360 +0.1
ABID97_RS27595 -0.1
ABID97_RS27655 -1.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information