MetaCyc Pathway: TCA cycle III (animals) in Variovorax sp. OAS795

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Reactions and Genes D,L-Malic Acid (C)
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2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
ABID97_RS01385 -0.1
ABID97_RS01390 -0.1
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
ABID97_RS02240 N.D.
ABID97_RS02245 N.D.
ABID97_RS24470 +0.1
ABID97_RS24475 +0.6
Succinate--CoA ligase (GDP-forming) (in reverse):
succinyl-CoA + GDP + phosphate→succinate + coenzyme A + GTP (EC 6.2.1.4)
No genes
Succinate dehydrogenase (ubiquinone):
succinate[in] + a ubiquinone→fumarate[in] + a ubiquinol (EC 1.3.5.1)
ABID97_RS08495 N.D.
ABID97_RS27720 -0.7
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
ABID97_RS17545 +1.2
ABID97_RS17550 -0.2
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
ABID97_RS05795 -0.2
ABID97_RS08515 N.D.
ABID97_RS17295 +0.1
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
ABID97_RS01110 +0.6
ABID97_RS01120 +0.5
ABID97_RS07945 +0.4
ABID97_RS08480 -2.0
ABID97_RS26895 -0.3
ABID97_RS28890 +0.3
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
ABID97_RS08535 N.D.
ABID97_RS08550 +1.6
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
ABID97_RS08535 N.D.
ABID97_RS08550 +1.6
Isocitrate--homoisocitrate dehydrogenase:
D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
ABID97_RS07480 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information