MetaCyc Pathway: 4-coumarate degradation (aerobic) in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
ABID97_RS28960 +0.1
(E)-4-coumaroyl-CoA + H2O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)
ABID97_RS24015 +0.3
3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA→4-hydroxybenzaldehyde + acetyl-CoA (EC 4.1.2.61)
ABID97_RS24015 +0.3
Vanillin dehydrogenase:
4-hydroxybenzaldehyde + NAD(P)+ + H2O→4-hydroxybenzoate + NAD(P)H + 2 H+ (EC 1.2.1.67)
ABID97_RS24600 -0.1
4-hydroxybenzoate 3-monooxygenase:
4-hydroxybenzoate + NADPH + dioxygen + H+→protocatechuate + NADP+ + H2O (EC 1.14.13.2)
ABID97_RS14945 -7.1
ABID97_RS24590 -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information