MetaCyc Pathway: palmitate biosynthesis II (type II fatty acid synthase) in Rhizobium sp. OAE497

Add experiment(s):


Reactions and Genes L-Tryptophan (C)
remove
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil] (EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate (EC 6.2.1.2; 6.2.1.3)
ABIE40_RS02155 -5.2
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
ABIE40_RS00380 N.D.
ABIE40_RS09445 +0.2
ABIE40_RS11070 -1.4
ABIE40_RS11075 -0.6
ABIE40_RS21125 +0.3
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+ (EC 1.1.1.100)
ABIE40_RS01520 +0.1
ABIE40_RS03480 -0.2
ABIE40_RS05040 -0.9
ABIE40_RS05275 -0.4
ABIE40_RS05510 -0.2
ABIE40_RS05770 -0.1
ABIE40_RS06360 N.D.
ABIE40_RS08095 -0.0
ABIE40_RS08220 +0.0
ABIE40_RS09580 -0.0
ABIE40_RS14115 +0.1
ABIE40_RS14130 -0.3
ABIE40_RS14900 -0.2
ABIE40_RS15230 +0.1
ABIE40_RS15970 -0.2
ABIE40_RS17065 +0.1
ABIE40_RS17875 +0.0
ABIE40_RS19545 +0.1
ABIE40_RS22535 +0.3
ABIE40_RS22690 +0.3
ABIE40_RS22790 +0.2
ABIE40_RS23495 +0.1
ABIE40_RS24200 +0.5
ABIE40_RS26290 -0.5
ABIE40_RS26695 +0.0
ABIE40_RS27890 -0.4
ABIE40_RS27920 +0.7
ABIE40_RS28015 +0.3
ABIE40_RS29325 -0.2
ABIE40_RS29620 -0.2
ABIE40_RS29645 -0.3
ABIE40_RS29650 -0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
ABIE40_RS00385 N.D.
ABIE40_RS08950 N.D.
ABIE40_RS11080 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+ (EC 1.3.1.9)
ABIE40_RS00375 N.D.
ABIE40_RS04000 N.D.
ABIE40_RS25330 -0.2
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
ABIE40_RS02155 -5.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information