MetaCyc Pathway: TCA cycle VIII (Chlamydia) in Escherichia coli BW25113
| Reactions and Genes | casaminos (C) |
|---|---|
| remove | |
| 2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105) | |
| b0116 (lpd) | N.D. |
| Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5) | |
| b0728 (sucC) | -4.0 |
| b0729 (sucD) | -4.2 |
| Succinate dehydrogenase (ubiquinone): succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1) | |
| No genes | |
| Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2) | |
| b1611 (fumC) | +0.3 |
| b1612 (fumA) | -1.8 |
| b1675 (ydhZ) | -0.3 |
| b2929 (yggD) | -0.2 |
| b4122 (fumB) | -0.2 |
| Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38) | |
| b0801 (ybiC) | -0.1 |
| b1479 (sfcA) | -0.2 |
| b3236 (mdh) | -3.1 |
| Aspartate transaminase (in reverse): oxaloacetate + L-glutamate→2-oxoglutarate + L-aspartate (EC 2.6.1.1) | |
| b0928 (aspC) | -2.2 |
| b4340 (yjiR) | +0.1 |
Links:
- Pathway details at MetaCyc
- Fitness data for 13 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information