MetaCyc Pathway: TCA cycle III (animals) in Escherichia coli BW25113

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Reactions and Genes casaminos (C)
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2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
b0116 (lpd) N.D.
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
b0728 (sucC) -4.6
b0729 (sucD) -4.6
Succinate--CoA ligase (GDP-forming) (in reverse):
succinyl-CoA + GDP + phosphate→succinate + coenzyme A + GTP (EC 6.2.1.4)
No genes
Succinate dehydrogenase (ubiquinone):
succinate[in] + a ubiquinone→fumarate[in] + a ubiquinol (EC 1.3.5.1)
b0723 (sdhA) -3.0
b4154 (frdA) +0.1
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
b1611 (fumC) -0.0
b1612 (fumA) -2.0
b1675 (ydhZ) -0.1
b2929 (yggD) -0.1
b4122 (fumB) +0.1
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
b0801 (ybiC) -0.0
b1479 (sfcA) +0.1
b3236 (mdh) -3.1
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
b0720 (gltA) -2.4
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
b0118 (acnB) -3.0
b0771 (ybhJ) +0.0
b1276 (acnA) -0.1
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
b0118 (acnB) -3.0
b0771 (ybhJ) +0.0
b1276 (acnA) -0.1
Isocitrate--homoisocitrate dehydrogenase:
D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information