MetaCyc Pathway: L-methionine biosynthesis II in Escherichia coli BW25113

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Reactions and Genes D-Serine (C)
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Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
b0003 (thrB) -3.5
Cystathionine gamma-synthase:
O-phospho-L-homoserine + L-cysteine→L-cystathionine + phosphate (EC 2.5.1.48)
b3939 (metB) -1.2
Cysteine-S-conjugate beta-lyase:
L-cystathionine→2-aminoprop-2-enoate + L-homocysteine (EC 4.4.1.13)
No genes
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
b3829 (metE) -3.9
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
b1814 (sdaA) -0.1
b1919 (yedO) -0.3
b2366 (dsdA) -4.5
b2797 (sdaB) -0.1
b3708 (tnaA) -0.2
b4471 (tdcG) -0.0
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
b1814 (sdaA) -0.1
b1919 (yedO) -0.3
b2366 (dsdA) -4.5
b2797 (sdaB) -0.1
b3113 (yhaR) +0.1
b3708 (tnaA) -0.2
b4243 (yjgF) -3.0
b4471 (tdcG) -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information