MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Serratia liquefaciens MT49

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Reactions and Genes Cadmium acetate 40 uM, aerobic
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
IAI46_03955 -1.4
IAI46_06405 -1.0
IAI46_11105 +0.3
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
IAI46_23700 -2.0
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
IAI46_03615 N.D.
IAI46_22745 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
IAI46_21700 +0.2
IAI46_23240 -3.7
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
IAI46_04655 +0.8
IAI46_23705 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
IAI46_08640 -2.5
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
IAI46_18025 -3.4
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
IAI46_03960 -1.8
IAI46_03965 -0.7
IAI46_10595 -0.4
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
IAI46_03965 -0.7
IAI46_22940 +0.1
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
IAI46_00175 -0.1
IAI46_00985 -0.1
IAI46_06940 -0.1
IAI46_07315 +0.1
IAI46_08205 -1.7
IAI46_08750 -0.0
IAI46_10415 -0.0
IAI46_14690 -0.7
IAI46_15405 -0.0
IAI46_16415 -0.7
IAI46_16430 +0.6
IAI46_17720 +0.4
IAI46_17905 +0.1
IAI46_17940 +0.1
IAI46_19310 -0.0
IAI46_19885 -0.2
IAI46_22930 -0.7
IAI46_24350 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information