MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Serratia liquefaciens MT49

Add experiment(s):


Reactions and Genes Cadmium acetate 40 uM, aerobic
remove
a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
IAI46_06535 +0.2
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
IAI46_04090 +0.0
IAI46_04105 +0.0
IAI46_08850 -0.1
IAI46_09800 +1.4
IAI46_15470 +0.2
IAI46_17995 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
IAI46_00395 -0.1
IAI46_02715 +0.1
IAI46_02810 -0.1
IAI46_03145 +0.3
IAI46_04100 +0.0
IAI46_05430 +0.1
IAI46_05725 -0.0
IAI46_07125 +0.4
IAI46_09790 N.D.
IAI46_10535 +0.0
IAI46_12450 +0.2
IAI46_17490 -0.0
IAI46_19920 -0.2
IAI46_21070 -0.1
IAI46_22865 +0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
IAI46_08860 N.D.
IAI46_12205 -0.6
IAI46_20205 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
IAI46_04090 +0.0
IAI46_04105 +0.0
IAI46_08850 -0.1
IAI46_09800 +1.4
IAI46_15470 +0.2
IAI46_17995 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
IAI46_00395 -0.1
IAI46_02715 +0.1
IAI46_02810 -0.1
IAI46_03145 +0.3
IAI46_04100 +0.0
IAI46_05430 +0.1
IAI46_05725 -0.0
IAI46_07125 +0.4
IAI46_09790 N.D.
IAI46_10535 +0.0
IAI46_12450 +0.2
IAI46_17490 -0.0
IAI46_19920 -0.2
IAI46_21070 -0.1
IAI46_22865 +0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
IAI46_08860 N.D.
IAI46_12205 -0.6
IAI46_20205 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
No genes
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
IAI46_23825 -0.1
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
IAI46_06530 -0.2
IAI46_16540 +0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information