MetaCyc Pathway: 4-hydroxy-2(1H)-quinolone biosynthesis in Pontibacter actiniarum KMM 6156, DSM 19842

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Reactions and Genes m.b. Chloride 750 mM
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Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
CA264_05055 -1.3
CA264_05060 -1.6
CA264_15260 -0.5
Anthranilate--CoA ligase:
anthranilate + ATP + coenzyme A→anthraniloyl-CoA + AMP + diphosphate (EC 6.2.1.32)
No genes
anthraniloyl-CoA + a [PqsD protein]-L-cysteine→a [PqsD protein]-S-anthraniloyl-L-cysteine + coenzyme A (EC 2.3.1.262)
No genes
a [PqsD protein]-S-anthraniloyl-L-cysteine + malonyl-CoA + H+→(2-aminobenzoyl)acetyl-CoA + CO2 + a [PqsD protein]-L-cysteine (EC 2.3.1.262)
No genes
(2-aminobenzoyl)acetyl-CoA→4-hydroxyquinolin-2(1H)-one + coenzyme A (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information