MetaCyc Pathway: 2-oxobutanoate degradation I in Pontibacter actiniarum KMM 6156, DSM 19842

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Reactions and Genes m.b. Chloride 750 mM
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2-oxoisovalerate dehydrogenase (acylating):
2-oxobutanoate + coenzyme A + NAD+→propanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
Propionyl-CoA carboxylase:
propanoyl-CoA + ATP + hydrogen carbonate→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
CA264_05220 N.D.
CA264_13085 -1.7
CA264_14425 N.D.
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
CA264_11050 -0.1
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
CA264_07155 -0.1
CA264_20690 -0.1
CA264_20695 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information