MetaCyc Pathway: benzoate fermentation (to acetate and cyclohexane carboxylate) in Variovorax sp. OAS795

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Reactions and Genes L-Tryptophan (C)
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Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
ABID97_RS03095 -0.2
benzoyl-CoA + 2 ATP + 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H2O→cyclohex-1,5-diene-1-carbonyl-CoA + 2 ADP + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 phosphate (EC 1.3.7.8)
No genes
Cyclohexa-1,5-dienecarbonyl-CoA hydratase (in reverse):
cyclohex-1,5-diene-1-carbonyl-CoA + H2O→6-hydroxycyclohex-1-ene-1-carbonyl-CoA (EC 4.2.1.100)
No genes
cyclohex-1,5-diene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohex-1-ene-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.10)
No genes
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+→6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ (EC 1.1.1.368)
No genes
cyclohex-1-ene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohexane-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.11)
No genes
cyclohexane-1-carbonyl-CoA + H2O→cyclohexane-1-carboxylate + coenzyme A + H+
No genes
6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O→2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA (EC 3.7.1.21)
No genes
2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O→3-hydroxypimeloyl-CoA + H+ (EC 3.7.1.21)
No genes
3-hydroxypimeloyl-CoA dehydrogenase:
3-hydroxypimeloyl-CoA + NAD+→3-oxopimeloyl-CoA + NADH + H+ (EC 1.1.1.259)
No genes
3-oxopimeloyl-CoA + coenzyme A→glutaryl-CoA + acetyl-CoA
ABID97_RS05875 N.D.
ABID97_RS15750 -0.1
ABID97_RS27835 -0.4
glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)
No genes
(E)-glutaconyl-CoA + H+→crotonyl-CoA + CO2 (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
ABID97_RS00815 -0.2
ABID97_RS01435 -6.3
ABID97_RS02880 -0.1
ABID97_RS04670 -0.1
ABID97_RS05865 -0.2
ABID97_RS05900 -0.5
ABID97_RS05990 -0.1
ABID97_RS06010 -0.0
ABID97_RS07755 +0.3
ABID97_RS10620 N.D.
ABID97_RS15740 -0.3
ABID97_RS17010 -0.2
ABID97_RS17470 -0.3
ABID97_RS18490 -0.2
ABID97_RS18600 +0.0
ABID97_RS18605 N.D.
ABID97_RS18635 -0.0
ABID97_RS20990 -0.0
ABID97_RS22770 +0.1
ABID97_RS24015 +0.2
ABID97_RS24805 +0.1
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 -0.2
ABID97_RS27555 -0.5
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.9
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS00810 N.D.
ABID97_RS03030 -0.0
ABID97_RS05865 -0.2
ABID97_RS06010 -0.0
ABID97_RS08805 +0.3
ABID97_RS10560 +0.1
ABID97_RS15740 -0.3
ABID97_RS17005 -0.4
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 +0.1
ABID97_RS05875 N.D.
ABID97_RS06005 +0.0
ABID97_RS10975 +0.2
ABID97_RS11335 -0.2
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 -0.1
ABID97_RS18615 -0.6
ABID97_RS18775 +0.2
ABID97_RS20240 -0.1
ABID97_RS24190 -0.0
ABID97_RS25195 -0.1
ABID97_RS26575 N.D.
ABID97_RS27835 -0.4
ABID97_RS28230 +0.5
ABID97_RS28270 -0.1
ABID97_RS28430 -0.0
Acetate--CoA ligase (ADP-forming) (in reverse):
acetyl-CoA + ADP + phosphate→acetate + ATP + coenzyme A (EC 6.2.1.13)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information