MetaCyc Pathway: dTMP de novo biosynthesis (mitochondrial) in Variovorax sp. OAS795

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Reactions and Genes L-Phenylalanine (C)
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Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3)
ABID97_RS02965 +0.4
ABID97_RS06515 -6.0
ABID97_RS10035 N.D.
ABID97_RS11755 N.D.
ABID97_RS27230 N.D.
Glycine hydroxymethyltransferase:
a tetrahydrofolate + L-serine→a 5,10-methylenetetrahydrofolate + glycine + H2O (EC 2.1.2.1)
ABID97_RS17890 N.D.
Thymidylate synthase:
a 5,10-methylenetetrahydrofolate + dUMP→a 7,8-dihydrofolate + dTMP (EC 2.1.1.45)
ABID97_RS10040 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information