MetaCyc Pathway: TCA cycle VI (Helicobacter) in Escherichia coli BW25113

Reactions and Genes	succinate (C)
2-oxoglutarate synthase: 2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
3-oxoacid CoA-transferase: succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
No genes
Succinate dehydrogenase (ubiquinone) (in reverse): succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
b4151 (frdD)	+0.1
b4152 (frdC)	+0.3
b4153 (frdB)	+0.1
b4154 (frdA)	+0.4
Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2)
b1611 (fumC)	+0.4
b1612 (fumA)	-1.7
b1675 (ydhZ)	-0.4
b2929 (yggD)	-0.0
b4122 (fumB)	-0.0
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
b2210 (mqo)	+0.1
Citrate (Si)-synthase: oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
b0720 (gltA)	-2.1
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
b0118 (acnB)	-3.0
b0771 (ybhJ)	+0.0
b1276 (acnA)	+0.2
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
b0118 (acnB)	-3.0
b0771 (ybhJ)	+0.0
b1276 (acnA)	+0.2
Isocitrate dehydrogenase (NADP(+)): D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
b1136 (icd)	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information