MetaCyc Pathway: L-leucine degradation III in Escherichia coli BW25113
| Reactions and Genes | succinate (C) |
|---|---|
| remove | |
| Branched-chain-amino-acid transaminase: L-leucine + 2-oxoglutarate→4-methyl-2-oxopentanoate + L-glutamate (EC 2.6.1.42; 2.6.1.6) | |
| b4054 (tyrB) | -1.1 |
| b3770 (ilvE) | -4.6 |
| Branched-chain-2-oxoacid decarboxylase: 4-methyl-2-oxopentanoate + H+→3-methylbutanal + CO2 (EC 4.1.1.72) | |
| No genes | |
| Alcohol dehydrogenase (in reverse): 3-methylbutanal + NADH + H+→3-methylbutanol + NAD+ (EC 1.1.1.1) | |
| b0325 (yahK) | +0.1 |
| b0356 (frmA) | +0.1 |
| b1241 (adhE) | +1.0 |
| b1478 (adhP) | -0.1 |
| b3253 (yhdH) | +0.1 |
| b4269 (yjgB) | -0.0 |
| b3589 (yiaY) | +0.0 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information