MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Variovorax sp. OAS795

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Reactions and Genes L-Leucine (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
ABID97_RS28960 +0.3
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
ABID97_RS00815 +0.1
ABID97_RS01435 -0.2
ABID97_RS02880 +0.0
ABID97_RS03115 -0.8
ABID97_RS04670 -0.3
ABID97_RS05865 -0.3
ABID97_RS05900 -0.0
ABID97_RS05990 -0.2
ABID97_RS06010 -0.0
ABID97_RS07755 -0.1
ABID97_RS10620 N.D.
ABID97_RS14445 -0.1
ABID97_RS15740 -0.4
ABID97_RS17005 -0.4
ABID97_RS17010 +0.3
ABID97_RS17470 -0.2
ABID97_RS18490 +0.4
ABID97_RS18595 N.D.
ABID97_RS18600 +0.2
ABID97_RS18605 N.D.
ABID97_RS18635 +0.1
ABID97_RS19410 -1.9
ABID97_RS20990 -0.3
ABID97_RS22770 -0.0
ABID97_RS24015 +0.5
ABID97_RS24805 -2.0
ABID97_RS26735 N.D.
ABID97_RS27490 -0.0
ABID97_RS27535 -0.3
ABID97_RS27555 +0.3
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.2
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS03030 -0.0
ABID97_RS05865 -0.3
ABID97_RS06010 -0.0
ABID97_RS08805 +0.1
ABID97_RS10560 -0.6
ABID97_RS15740 -0.4
ABID97_RS17005 -0.4
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
ABID97_RS04675 +0.2
ABID97_RS05875 N.D.
ABID97_RS06005 -0.1
ABID97_RS10975 +0.1
ABID97_RS11335 +0.0
ABID97_RS11380 -0.2
ABID97_RS12420 N.D.
ABID97_RS15750 -0.4
ABID97_RS18615 -0.2
ABID97_RS18775 +0.4
ABID97_RS20240 -0.0
ABID97_RS24190 -0.3
ABID97_RS25195 -0.5
ABID97_RS26575 N.D.
ABID97_RS27835 -0.1
ABID97_RS28230 +0.9
ABID97_RS28270 +0.0
ABID97_RS28430 +0.0
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
ABID97_RS03095 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information