MetaCyc Pathway: superpathway of pentose and pentitol degradation in Escherichia coli BW25113

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Reactions and Genes succinate (C)
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D-arabinitol 4-dehydrogenase:
D-arabinitol + NAD+→D-xylulose + NADH + H+
(EC 1.1.1.11)
No genes
Arabinose isomerase:
D-arabinopyranose→D-ribulose
(EC 5.3.1.3)
b2802 (fucI) +0.2
β-L-lyxopyranose→L-xylulose
b3903 (rhaA) N.D.
Ribitol 2-dehydrogenase:
ribitol + NAD+→D-ribulose + NADH + H+
(EC 1.1.1.56)
No genes
D-xylopyranose + NAD(P)+→D-xylono-1,5-lactone + NAD(P)H + H+ (EC 1.1.1.359)
No genes
D-arabinopyranose→D-arabinofuranose (spontaneous)
No genes
L-arabinofuranose→L-arabinopyranose (spontaneous)
No genes
D-xylopyranose + NADP+→D-xylono-1,4-lactone + NADPH + H+ (EC 1.1.1.424)
No genes
Aldehyde reductase (in reverse):
L-arabinose + NADPH + H+→L-arabinitol + NADP+
(EC 1.1.1.21)
No genes
D-xylose + NADPH + H+→xylitol + NADP+ (EC 1.1.1.431)
No genes
Xylose isomerase:
α-D-xylopyranose→α-D-xylulofuranose
(EC 5.3.1.5)
b3565 (xylA) -0.2
L-arabinose isomerase:
β-L-arabinopyranose→L-ribulose
(EC 5.3.1.4)
b0062 (araA) N.D.
D-ribulokinase:
D-ribulose + ATP→D-ribulose 5-phosphate + ADP + H+
(EC 2.7.1.47)
b0063 (araB) N.D.
L-fuculokinase:
D-ribulose + ATP→D-ribulose 1-phosphate + ADP + H+
(EC 2.7.1.51)
b2803 (fucK) +0.4
L-arabinitol 4-dehydrogenase:
L-arabinitol + NAD+→L-xylulose + NADH + H+
(EC 1.1.1.12)
No genes
D-xylono-1,5-lactone + H2O→D-xylonate + H+ (EC 3.1.1.110)
No genes
Xylono-1,4-lactonase:
D-xylono-1,4-lactone + H2O→D-xylonate + H+
(EC 3.1.1.68)
No genes
α-L-arabinopyranose + NAD(P)+→L-arabinono-1,4-lactone + NAD(P)H + H+ (EC 1.1.1.376)
No genes
D-arabinofuranose + NADP+→D-arabinono-1,4-lactone + NADPH + H+ (EC 1.1.1.427)
No genes
D-arabinonolactonase:
D-arabinono-1,4-lactone + H2O→D-arabinonate + H+
(EC 3.1.1.30)
No genes
L-fuculose-phosphate aldolase:
D-ribulose 1-phosphate→glycerone phosphate + glycolaldehyde
(EC 4.1.2.17)
b2800 (fucA) +0.0
L-arabinonolactonase:
L-arabinono-1,4-lactone + H2O→L-arabinonate + H+
(EC 3.1.1.15)
No genes
L-xylulose reductase (in reverse):
L-xylulose + NADPH + H+→xylitol + NADP+
(EC 1.1.1.10)
No genes
L-xylulokinase:
L-xylulose + ATP→L-xylulose 5-phosphate + ADP + H+
(EC 2.7.1.53)
b3580 (lyxK) +0.3
Ribulokinase:
L-ribulose + ATP→L-ribulose 5-phosphate + ADP + H+
(EC 2.7.1.16)
b0063 (araB) N.D.
Xylonate dehydratase:
D-xylonate→2-dehydro-3-deoxy-D-pentonate + H2O
(EC 4.2.1.82)
b0269 (yagF) +0.0
b4297 (yjhG) +0.0
2-dehydro-3-deoxy-D-pentonate aldolase:
2-dehydro-3-deoxy-D-pentonate→glycolaldehyde + pyruvate
(EC 4.1.2.28)
b0268 (yagE) -0.4
b4298 (yjhH) -0.0
Arabinonate dehydratase:
D-arabinonate→2-dehydro-3-deoxy-D-pentonate + H2O
(EC 4.2.1.5)
No genes
D-xylulose reductase:
xylitol + NAD+→D-xylulose + NADH + H+
(EC 1.1.1.9)
No genes
L-arabinonate dehydratase:
L-arabinonate→2-dehydro-3-deoxy-L-pentonate + H2O
(EC 4.2.1.25)
No genes
L-ribulose-5-phosphate 3-epimerase (in reverse):
L-xylulose 5-phosphate→L-ribulose 5-phosphate
(EC 5.1.3.22)
b3582 (sgbU) +0.0
b4197 (ulaE) -0.1
2-dehydro-3-deoxy-L-pentonate aldolase:
2-dehydro-3-deoxy-L-pentonate→glycolaldehyde + pyruvate
(EC 4.1.2.18)
No genes
2-dehydro-3-deoxy-L-arabinonate dehydratase:
2-dehydro-3-deoxy-L-pentonate→2,5-dioxopentanoate + H2O
(EC 4.2.1.43)
No genes
L-ribulose-5-phosphate 4-epimerase:
L-ribulose 5-phosphate→D-xylulose 5-phosphate
(EC 5.1.3.4)
b0061 (araD) +0.0
b3583 (sgbE) -0.2
b4198 (ulaF) -0.1
2-dehydro-3-deoxy-D-pentonate→2,5-dioxopentanoate + H2O (EC 4.2.1.141)
No genes
Xylulokinase:
D-xylulose + ATP→D-xylulose 5-phosphate + ADP + H+
(EC 2.7.1.17)
b3564 (xylB) -0.0
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+
(EC 1.2.1.26)
No genes
Glycolaldehyde dehydrogenase:
glycolaldehyde + NAD+ + H2O→glycolate + NADH + 2 H+
(EC 1.2.1.21)
b1415 (aldA) +0.3
glycolaldehyde + an oxidized electron carrier→glycolate + a reduced two electron carrier + H+
No genes
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NAD(P)+ + H2O→2-oxoglutarate + NAD(P)H + 2 H+
(EC 1.2.1.26)
No genes
Glyoxylate reductase:
glycolate + NAD+→glyoxylate + NADH + H+
(EC 1.1.1.26)
No genes
Malate synthase:
glyoxylate + acetyl-CoA + H2O→(S)-malate + coenzyme A + H+
(EC 2.3.3.9)
b2976 (glcB) -0.2
b4014 (aceB) +1.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information