MetaCyc Pathway: superpathway of L-threonine biosynthesis in Variovorax sp. OAS795

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Reactions and Genes L-Threonine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
ABID97_RS04080 -0.3
ABID97_RS05635 -0.3
ABID97_RS06550 +0.0
ABID97_RS10885 -1.9
ABID97_RS13335 -0.0
ABID97_RS16605 -1.0
ABID97_RS17960 -0.5
ABID97_RS18035 +0.4
ABID97_RS20530 -0.3
ABID97_RS21960 +0.5
ABID97_RS24840 -0.0
ABID97_RS27360 +0.1
ABID97_RS27595 +0.2
ABID97_RS27655 -0.3
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
ABID97_RS17825 N.D.
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
ABID97_RS08450 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
ABID97_RS10890 N.D.
ABID97_RS12480 -4.7
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
ABID97_RS09170 N.D.
ABID97_RS25765 -0.1
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
ABID97_RS10895 N.D.
ABID97_RS25760 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information