MetaCyc Pathway: serotonin degradation in Pseudomonas simiae WCS417

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Reactions and Genes Fumarate (C)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
PS417_07290 -0.1
PS417_11170 +0.2
PS417_14675 +0.1
PS417_17430 -0.3
PS417_18205 +0.7
PS417_24810 -0.6
PS417_02645 +0.0
PS417_26845 +0.1
PS417_27745 -0.0
PS417_04200 +0.1
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
PS417_06330 +0.2
PS417_06905 -0.0
PS417_11230 +0.0
PS417_17420 -2.3
PS417_18270 -0.1
PS417_21315 +0.0
PS417_25740 +0.1
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information