MetaCyc Pathway: lactate fermentation to acetate, CO2 and hydrogen (Desulfovibrionales) in Escherichia coli BW25113

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Reactions and Genes D-Lactate (C)
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D-lactate dehydrogenase (cytochrome c-553):
(R)-lactate + 2 an oxidized cytochrome c-553→pyruvate + 2 H+ + 2 a reduced cytochrome c-553 (EC 1.1.2.5)
b1380 (ldhA) +0.6
b2133 (dld) -1.4
L-lactate dehydrogenase (cytochrome):
(S)-lactate + 2 an oxidized c-type cytochrome→pyruvate + 2 a reduced c-type cytochrome + 2 H+ (EC 1.1.2.3)
b3605 (lldD) +0.3
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + 2 a reduced ferredoxin [iron-sulfur] cluster + H+ (EC 1.2.7.1)
b1378 (ydbK) +0.1
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
b2297 (pta) -2.8
b2458 (eutI) +0.1
CO2 + 2 a reduced type I cytochrome c3 + H+→formate + 2 an oxidized type I cytochrome c3 (EC 1.17.2.3)
No genes
a reduced ferredoxin [iron-sulfur] cluster + an oxidized type I cytochrome c3→a reduced type I cytochrome c3 + an oxidized ferredoxin [iron-sulfur] cluster
No genes
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
b1849 (purT) +0.1
b2296 (ackA) N.D.
b2460 (eutQ) -0.0
b2461 (eutP) -0.1
b3115 (tdcD) -0.1
Cytochrome-c3 hydrogenase (in reverse):
2 a reduced type I cytochrome c3 + 2 H+→H2 + 2 an oxidized type I cytochrome c3 (EC 1.12.2.1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information