MetaCyc Pathway: serotonin degradation in Pseudomonas fluorescens GW456-L13

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Reactions and Genes Putrescine (C)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
PfGW456L13_1045 +0.2
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
PfGW456L13_127 -0.1
PfGW456L13_1342 -0.5
PfGW456L13_1397 +0.1
PfGW456L13_1795 +0.7
PfGW456L13_2360 -0.2
PfGW456L13_2419 -0.2
PfGW456L13_2690 +0.1
PfGW456L13_2713 +0.1
PfGW456L13_3141 -0.4
PfGW456L13_3205 -0.2
PfGW456L13_3440 +0.4
PfGW456L13_3517 -1.7
PfGW456L13_3604 -0.5
PfGW456L13_3737 +0.1
PfGW456L13_5044 +0.1
PfGW456L13_805 -2.8
PfGW456L13_985 -0.2
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
PfGW456L13_1214 -0.1
PfGW456L13_2132 -0.3
PfGW456L13_2712 +0.3
PfGW456L13_2913 -0.5
PfGW456L13_3512 +0.4
PfGW456L13_3630 +0.3
PfGW456L13_4682 +0.1
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information