MetaCyc Pathway: NAD salvage pathway II (PNC IV cycle) in Escherichia coli BW25113

Reactions and Genes	acetate (C)
NAD(+) synthase (glutamine-hydrolyzing): nicotinate adenine dinucleotide + ATP + L-glutamine + H2O→NAD+ + AMP + L-glutamate + diphosphate + H+ (EC 6.3.5.1)
No genes
NAD(+) diphosphatase: NAD+ + H2O→β-nicotinamide D-ribonucleotide + AMP + 2 H+ (EC 3.6.1.22)
b2411 (ligA)	N.D.
b3996 (nudC)	-1.0
Nicotinamide-nucleotide amidase: β-nicotinamide D-ribonucleotide + H2O→β-nicotinate D-ribonucleotide + ammonium (EC 3.5.1.42)
b1537 (ydeJ)	-0.4
b2700 (ygaD)	+0.4
Nicotinate-nucleotide adenylyltransferase: β-nicotinate D-ribonucleotide + ATP + H+→nicotinate adenine dinucleotide + diphosphate (EC 2.7.7.18)
b0639 (nadD)	N.D.
NAD(+) synthase: nicotinate adenine dinucleotide + ammonium + ATP→NAD+ + AMP + diphosphate + H+ (EC 6.3.1.5)
b1740 (nadE)	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information