MetaCyc Pathway: L-valine degradation I in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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Branched-chain-amino-acid transaminase:
L-valine + 2-oxoglutarate→3-methyl-2-oxobutanoate + L-glutamate (EC 2.6.1.42)
ABID97_RS03790 -2.4
2-oxoisovalerate dehydrogenase (acylating):
3-methyl-2-oxobutanoate + coenzyme A + NAD+→isobutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
isobutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→methylacrylyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
methylacrylyl-CoA + H2O→(S)-3-hydroxy-isobutanoyl-CoA (EC 4.2.1.150)
ABID97_RS00815 +0.1
ABID97_RS01435 +0.1
ABID97_RS02880 +0.2
ABID97_RS04670 +0.0
ABID97_RS05865 -1.6
ABID97_RS05900 +0.0
ABID97_RS05990 -0.1
ABID97_RS06010 +0.3
ABID97_RS07755 +0.2
ABID97_RS10620 N.D.
ABID97_RS15740 -0.3
ABID97_RS17010 +0.0
ABID97_RS17470 +0.2
ABID97_RS18490 -0.2
ABID97_RS18600 +0.2
ABID97_RS18605 N.D.
ABID97_RS18635 -0.8
ABID97_RS20990 +0.5
ABID97_RS22770 +0.0
ABID97_RS24015 +0.4
ABID97_RS24805 +1.5
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 +0.6
ABID97_RS27555 -0.2
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.3
3-hydroxyisobutyryl-CoA hydrolase:
(S)-3-hydroxy-isobutanoyl-CoA + H2O→(S)-3-hydroxy-isobutanoate + coenzyme A + H+ (EC 3.1.2.4)
ABID97_RS19410 +0.6
3-hydroxyisobutyrate dehydrogenase:
(S)-3-hydroxy-isobutanoate + NAD+→(S)-methylmalonate-semialdehyde + NADH + H+ (EC 1.1.1.31)
ABID97_RS01185 +0.1
ABID97_RS01945 -0.2
ABID97_RS03030 +0.2
ABID97_RS05865 -1.6
ABID97_RS06010 +0.3
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS18595 N.D.
ABID97_RS19405 +0.5
ABID97_RS25480 +0.1
(S)-3-amino-2-methylpropionate transaminase (in reverse):
(S)-methylmalonate-semialdehyde + L-glutamate→(S)-3-amino-2-methylpropanoate + 2-oxoglutarate (EC 2.6.1.22)
ABID97_RS21585 -0.1
Methylmalonate-semialdehyde dehydrogenase (acylating):
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O→propanoyl-CoA + hydrogen carbonate + NADH + H+ (EC 1.2.1.27)
ABID97_RS19425 +0.1
ABID97_RS19485 +0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information