MetaCyc Pathway: TCA cycle VI (Helicobacter) in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
ABID97_RS28055 -0.1
ABID97_RS28060 +0.1
3-oxoacid CoA-transferase:
succinyl-CoA + acetoacetate→succinate + acetoacetyl-CoA (EC 2.8.3.5)
ABID97_RS19435 N.D.
ABID97_RS19440 -0.1
Succinate dehydrogenase (ubiquinone) (in reverse):
succinate[in] + a menaquinone→fumarate[in] + a menaquinol (EC 1.3.5.1)
No genes
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
ABID97_RS17545 -0.4
ABID97_RS17550 -0.3
(S)-malate + a menaquinone→oxaloacetate + a menaquinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
ABID97_RS01110 +0.2
ABID97_RS01120 -1.0
ABID97_RS07945 -1.6
ABID97_RS08480 -1.7
ABID97_RS26895 -0.1
ABID97_RS28890 +0.3
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
ABID97_RS08535 N.D.
ABID97_RS08550 -3.0
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
ABID97_RS08535 N.D.
ABID97_RS08550 -3.0
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
ABID97_RS16920 -3.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information