MetaCyc Pathway: phenylacetate degradation I (aerobic) in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
ABID97_RS01105 +0.6
ABID97_RS22780 +0.3
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
ABID97_RS22785 -0.0
ABID97_RS22790 +0.5
ABID97_RS22795 N.D.
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
ABID97_RS04670 +0.0
ABID97_RS22770 +0.0
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
ABID97_RS05990 -0.1
ABID97_RS17010 +0.0
ABID97_RS22830 -0.1
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
ABID97_RS22830 -0.1
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
ABID97_RS00815 +0.1
ABID97_RS01435 +0.1
ABID97_RS02880 +0.2
ABID97_RS03115 -0.3
ABID97_RS04670 +0.0
ABID97_RS05865 -1.6
ABID97_RS05900 +0.0
ABID97_RS05990 -0.1
ABID97_RS06010 +0.3
ABID97_RS07755 +0.2
ABID97_RS10620 N.D.
ABID97_RS14445 +0.3
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS17010 +0.0
ABID97_RS17470 +0.2
ABID97_RS18490 -0.2
ABID97_RS18595 N.D.
ABID97_RS18600 +0.2
ABID97_RS18605 N.D.
ABID97_RS18635 -0.8
ABID97_RS19410 +0.6
ABID97_RS20990 +0.5
ABID97_RS22770 +0.0
ABID97_RS24015 +0.4
ABID97_RS24805 +1.5
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 +0.6
ABID97_RS27555 -0.2
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS03030 +0.2
ABID97_RS05865 -1.6
ABID97_RS06010 +0.3
ABID97_RS08805 -0.1
ABID97_RS10560 -0.0
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS18595 N.D.
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
ABID97_RS24190 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information