MetaCyc Pathway: methyl tert-butyl ether degradation in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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methyl tert-butyl ether + NADH + dioxygen + H+→tert-butoxymethanol + NAD+ + H2O (EC 1.14.13.M36)
No genes
tert-butoxymethanol + NAD+→tert-butyl formate + NADH + H+ (EC 1.1.1.M26)
No genes
tert-butyl formate + H2O→tert-butyl alcohol + formate + H+
ABID97_RS00800 -0.2
tert-butyl alcohol + NADPH + dioxygen + H+→2-methylpropane-1,2-diol + NADP+ + H2O (EC 1.14.13.229)
No genes
2-methylpropane-1,2-diol + NAD+→2-hydroxy-2-methylpropanal + NADH + H+ (EC 1.1.1.400)
No genes
2-hydroxy-2-methylpropanal + NAD+ + H2O→2-hydroxy-2-methylpropanoate + NADH + 2 H+ (EC 1.2.1.98)
No genes
2-hydroxy-2-methylpropanoate + ATP + coenzyme A→2-hydroxy-2-methylpropanoyl-CoA + AMP + diphosphate (EC 6.2.1.M4)
No genes
2-hydroxy-2-methylpropanoyl-CoA→(S)-3-hydroxybutanoyl-CoA (EC 5.4.99.64)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS00810 N.D.
ABID97_RS03030 +0.2
ABID97_RS05865 -1.6
ABID97_RS06010 +0.3
ABID97_RS08805 -0.1
ABID97_RS10560 -0.0
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 +0.2
ABID97_RS05875 N.D.
ABID97_RS06005 +0.4
ABID97_RS10975 +0.0
ABID97_RS11335 +0.8
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 +0.1
ABID97_RS18615 -0.1
ABID97_RS18775 +0.4
ABID97_RS20240 -0.1
ABID97_RS24190 -0.2
ABID97_RS25195 +0.5
ABID97_RS26575 N.D.
ABID97_RS27835 +0.0
ABID97_RS28230 -0.4
ABID97_RS28270 -1.0
ABID97_RS28430 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information