MetaCyc Pathway: superpathway of salicylate degradation in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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Salicylate 1-monooxygenase:
salicylate + NADH + dioxygen + 2 H+→catechol + CO2 + NAD+ + H2O (EC 1.14.13.1)
ABID97_RS00055 +0.2
ABID97_RS01335 -0.4
ABID97_RS03970 +0.3
ABID97_RS04265 -0.1
ABID97_RS08580 N.D.
ABID97_RS13145 -0.0
ABID97_RS13210 -0.2
ABID97_RS13480 -1.0
ABID97_RS18805 -0.3
ABID97_RS28485 N.D.
ABID97_RS29355 -0.9
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1)
ABID97_RS13200 N.D.
ABID97_RS28895 +0.1
ABID97_RS29155 -0.3
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1)
No genes
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4)
ABID97_RS13085 +0.0
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24)
ABID97_RS11395 +0.0
ABID97_RS19695 -3.0
ABID97_RS23830 +0.2
ABID97_RS25555 N.D.
ABID97_RS27270 N.D.
ABID97_RS29170 +0.4
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6)
ABID97_RS13250 +0.3
ABID97_RS13255 -0.4
ABID97_RS24195 -5.8
ABID97_RS24200 -4.5
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174)
ABID97_RS24190 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information