MetaCyc Pathway: 3-hydroxypropanoate/4-hydroxybutanate cycle in Variovorax sp. OAS795

Add experiment(s):


Reactions and Genes 4-Hydroxybenzoic Acid (C)
remove
Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogen carbonate + H+ (EC 4.2.1.1)
ABID97_RS25185 N.D.
Biotin carboxylase:
hydrogen carbonate + ATP + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine→a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + ADP + H+ + phosphate (EC 6.3.4.14)
ABID97_RS00115 +0.2
ABID97_RS04150 -0.6
ABID97_RS06370 N.D.
ABID97_RS06375 N.D.
ABID97_RS12340 +0.4
ABID97_RS13950 -0.3
ABID97_RS27370 -0.5
ABID97_RS27375 N.D.
a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + acetyl-CoA→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
ABID97_RS08420 N.D.
ABID97_RS17835 N.D.
malonyl-CoA + NADPH + H+→3-oxopropanoate + coenzyme A + NADP+ (EC 1.2.1.75)
No genes
3-oxopropanoate + NADPH + H+→3-hydroxypropanoate + NADP+ (EC 1.1.1.298)
No genes
3-hydroxypropanoate + ATP + coenzyme A→3-hydroxypropanoyl-CoA + AMP + diphosphate (EC 6.2.1.36)
No genes
3-hydroxypropanoyl-CoA→acryloyl-CoA + H2O (EC 4.2.1.116)
ABID97_RS26735 N.D.
acryloyl-CoA + NADPH + H+→propanoyl-CoA + NADP+ (EC 1.3.1.84)
ABID97_RS13275 -0.1
Propionyl-CoA carboxylase:
hydrogen carbonate + propanoyl-CoA + ATP→(S)-methylmalonyl-CoA + ADP + H+ + phosphate (EC 6.4.1.3)
ABID97_RS08420 N.D.
ABID97_RS13945 -0.7
ABID97_RS13950 -0.3
ABID97_RS17835 N.D.
Methylmalonyl-CoA epimerase (in reverse):
(S)-methylmalonyl-CoA→(R)-methylmalonyl-CoA (EC 5.1.99.1)
ABID97_RS13960 N.D.
Methylmalonyl-CoA mutase:
(R)-methylmalonyl-CoA→succinyl-CoA (EC 5.4.99.2)
ABID97_RS13930 +0.2
succinyl-CoA + NADPH + H+→succinate semialdehyde + coenzyme A + NADP+ (EC 1.2.1.76)
No genes
succinate semialdehyde + NADPH + H+→4-hydroxybutanoate + NADP+ (EC 1.1.1.co)
No genes
4-hydroxybutanoate + ATP + coenzyme A→4-hydroxybutanoyl-CoA + AMP + diphosphate (EC 6.2.1.40)
No genes
4-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.120)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
ABID97_RS00815 +0.1
ABID97_RS01435 +0.1
ABID97_RS02880 +0.2
ABID97_RS04670 +0.0
ABID97_RS05865 -1.6
ABID97_RS05900 +0.0
ABID97_RS05990 -0.1
ABID97_RS06010 +0.3
ABID97_RS07755 +0.2
ABID97_RS10620 N.D.
ABID97_RS15740 -0.3
ABID97_RS17010 +0.0
ABID97_RS17470 +0.2
ABID97_RS18490 -0.2
ABID97_RS18600 +0.2
ABID97_RS18605 N.D.
ABID97_RS18635 -0.8
ABID97_RS20990 +0.5
ABID97_RS22770 +0.0
ABID97_RS24015 +0.4
ABID97_RS24805 +1.5
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 +0.6
ABID97_RS27555 -0.2
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.3
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS00810 N.D.
ABID97_RS03030 +0.2
ABID97_RS05865 -1.6
ABID97_RS06010 +0.3
ABID97_RS08805 -0.1
ABID97_RS10560 -0.0
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 +0.2
ABID97_RS05875 N.D.
ABID97_RS06005 +0.4
ABID97_RS10975 +0.0
ABID97_RS11335 +0.8
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 +0.1
ABID97_RS18615 -0.1
ABID97_RS18775 +0.4
ABID97_RS20240 -0.1
ABID97_RS24190 -0.2
ABID97_RS25195 +0.5
ABID97_RS26575 N.D.
ABID97_RS27835 +0.0
ABID97_RS28230 -0.4
ABID97_RS28270 -1.0
ABID97_RS28430 -0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information