MetaCyc Pathway: L-glutamate degradation V (via hydroxyglutarate) in Variovorax sp. OAS795

Add experiment(s):


Reactions and Genes 4-Hydroxybenzoic Acid (C)
remove
Glutamate dehydrogenase:
L-glutamate + NAD+ + H2O→2-oxoglutarate + ammonium + NADH + H+ (EC 1.4.1.2)
ABID97_RS00235 +0.9
2-oxoglutarate + NADH + H+→(R)-2-hydroxyglutarate + NAD+ (EC 1.1.1.399)
ABID97_RS07235 +0.1
Glutaconate CoA-transferase:
(R)-2-hydroxyglutarate + acetyl-CoA→(R)-2-hydroxyglutaryl-CoA + acetate (EC 2.8.3.12)
No genes
(R)-2-hydroxyglutaryl-CoA→(E)-glutaconyl-CoA + H2O (EC 4.2.1.167)
No genes
(E)-glutaconyl-CoA[in] + Na+[in] + H+[in]→crotonyl-CoA[in] + CO2[in] + Na+[out] (EC 7.2.4.5)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
ABID97_RS00815 +0.1
ABID97_RS01435 +0.1
ABID97_RS02880 +0.2
ABID97_RS04670 +0.0
ABID97_RS05865 -1.6
ABID97_RS05900 +0.0
ABID97_RS05990 -0.1
ABID97_RS06010 +0.3
ABID97_RS07755 +0.2
ABID97_RS10620 N.D.
ABID97_RS15740 -0.3
ABID97_RS17010 +0.0
ABID97_RS17470 +0.2
ABID97_RS18490 -0.2
ABID97_RS18600 +0.2
ABID97_RS18605 N.D.
ABID97_RS18635 -0.8
ABID97_RS20990 +0.5
ABID97_RS22770 +0.0
ABID97_RS24015 +0.4
ABID97_RS24805 +1.5
ABID97_RS26735 N.D.
ABID97_RS27490 +0.1
ABID97_RS27535 +0.6
ABID97_RS27555 -0.2
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 -0.3
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Propionate CoA-transferase:
butanoyl-CoA + acetate→acetyl-CoA + butanoate (EC 2.8.3.1; 2.8.3.8)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
ABID97_RS00810 N.D.
ABID97_RS03030 +0.2
ABID97_RS05865 -1.6
ABID97_RS06010 +0.3
ABID97_RS08805 -0.1
ABID97_RS10560 -0.0
ABID97_RS15740 -0.3
ABID97_RS17005 -0.5
ABID97_RS18595 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 +0.2
ABID97_RS05875 N.D.
ABID97_RS06005 +0.4
ABID97_RS10975 +0.0
ABID97_RS11335 +0.8
ABID97_RS11380 +0.1
ABID97_RS12420 N.D.
ABID97_RS15750 +0.1
ABID97_RS18615 -0.1
ABID97_RS18775 +0.4
ABID97_RS20240 -0.1
ABID97_RS24190 -0.2
ABID97_RS25195 +0.5
ABID97_RS26575 N.D.
ABID97_RS27835 +0.0
ABID97_RS28230 -0.4
ABID97_RS28270 -1.0
ABID97_RS28430 -0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information