MetaCyc Pathway: L-histidine biosynthesis in Variovorax sp. OAS795

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Reactions and Genes 4-Hydroxybenzoic Acid (C)
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ATP phosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + ATP→1-(5-phospho-β-D-ribosyl)-ATP + diphosphate (EC 2.4.2.17)
ABID97_RS14275 N.D.
ABID97_RS23165 N.D.
Phosphoribosyl-ATP diphosphatase:
1-(5-phospho-β-D-ribosyl)-ATP + H2O→1-(5-phospho-β-D-ribosyl)-AMP + diphosphate + H+ (EC 3.6.1.31)
ABID97_RS23095 N.D.
ABID97_RS23100 N.D.
Phosphoribosyl-AMP cyclohydrolase:
1-(5-phospho-β-D-ribosyl)-AMP + H2O→1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide (EC 3.5.4.19)
ABID97_RS23095 N.D.
ABID97_RS23100 N.D.
isomerase:
1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide→phosphoribulosylformimino-AICAR-phosphate (EC 5.3.1.16)
ABID97_RS12645 +0.2
ABID97_RS23130 N.D.
phosphoribulosylformimino-AICAR-phosphate + L-glutamine→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate + L-glutamate + H+ (EC 4.3.2.10)
ABID97_RS23105 N.D.
ABID97_RS23135 N.D.
Imidazoleglycerol-phosphate dehydratase:
D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate→3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (EC 4.2.1.19)
ABID97_RS23140 N.D.
Histidinol-phosphate transaminase (in reverse):
3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate→L-histidinol phosphate + 2-oxoglutarate (EC 2.6.1.9)
ABID97_RS08770 -3.7
ABID97_RS17385 +0.1
ABID97_RS23145 -0.1
Histidinol-phosphatase:
L-histidinol phosphate + H2O→histidinol + phosphate (EC 3.1.3.15)
ABID97_RS06535 N.D.
ABID97_RS25250 +0.8
Histidinol dehydrogenase:
histidinol + NAD+→histidinal + NADH + H+ (EC 1.1.1.23)
ABID97_RS23160 N.D.
Histidinol dehydrogenase:
histidinal + NAD+ + H2O→L-histidine + NADH + 2 H+ (EC 1.1.1.23)
ABID97_RS23160 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information