MetaCyc Pathway: dipicolinate biosynthesis in Escherichia coli BW25113

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Reactions and Genes D-Glucuronic Acid (C)
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
b0002 (thrA) -3.5
b3940 (metL) -0.5
b4024 (lysC) -1.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
b2319 (usg) -0.3
b3433 (asd) N.D.
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
b0268 (yagE) -0.1
b2478 (dapA) N.D.
b4298 (yjhH) -0.1
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD+→dipicolinate + NADH + H+ + H2O
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information