MetaCyc Pathway: superpathway of polyamine biosynthesis III in Escherichia coli BW25113

Reactions and Genes	D-Glucuronic Acid (C)
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Aspartate kinase: L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
b0002 (thrA)	-3.5
b3940 (metL)	-0.5
b4024 (lysC)	-1.2
Diaminobutyrate--2-oxoglutarate transaminase (in reverse): L-aspartate 4-semialdehyde + L-glutamate→L-2,4-diaminobutanoate + 2-oxoglutarate (EC 2.6.1.76)
No genes
Diaminobutyrate decarboxylase: L-2,4-diaminobutanoate + H⁺→propane-1,3-diamine + CO₂ (EC 4.1.1.86)
No genes
Aspartate-semialdehyde dehydrogenase (in reverse): L-aspartyl-4-phosphate + NADPH + H⁺→L-aspartate 4-semialdehyde + NADP⁺ + phosphate (EC 1.2.1.11)
b2319 (usg)	-0.3
b3433 (asd)	N.D.
propane-1,3-diamine + L-aspartate 4-semialdehyde + NADPH + H⁺→carboxynorspermidine + NADP⁺ + H₂O (EC 1.5.1.43)
No genes
L-aspartate 4-semialdehyde + putrescine + NADPH + H⁺→carboxyspermidine + NADP⁺ + H₂O (EC 1.5.1.43)
No genes
carboxyspermidine + H⁺→spermidine + CO₂ (EC 4.1.1.96)
No genes
carboxynorspermidine + H⁺→norspermidine + CO₂ (EC 4.1.1.96)
No genes

Links:

Pathway details at MetaCyc
Fitness data for 5 genes
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All MetaCyc pathways for Escherichia coli BW25113

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information