MetaCyc Pathway: superpathway of NAD biosynthesis in eukaryotes in Escherichia coli BW25113

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Reactions and Genes a-Ketoglutaric (C)
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Ribosylnicotinamide kinase:
1-(β-D ribofuranosyl)nicotinamide + ATP→β-nicotinamide D-ribonucleotide + ADP + H+ (EC 2.7.1.22)
b4390 (nadR) +1.3
Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52)
No genes
Nicotinamide-nucleotide adenylyltransferase:
β-nicotinamide D-ribonucleotide + ATP + H+→NAD+ + diphosphate (EC 2.7.7.1)
b4390 (nadR) +1.3
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9)
No genes
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9)
No genes
Kynureninase:
3-hydroxy-L-kynurenine + H2O→3-hydroxyanthranilate + L-alanine + H+ (EC 3.7.1.3)
No genes
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6)
No genes
2-amino-3-carboxymuconate-6-semialdehyde→quinolinate + H+ + H2O (spontaneous)
No genes
Nicotinate-nucleotide diphosphorylase (carboxylating) (in reverse):
quinolinate + 2 H+ + 5-phospho-α-D-ribose 1-diphosphate→β-nicotinate D-ribonucleotide + CO2 + diphosphate (EC 2.4.2.19)
b0109 (nadC) -1.2
Nicotinate-nucleotide adenylyltransferase:
β-nicotinate D-ribonucleotide + ATP + H+→nicotinate adenine dinucleotide + diphosphate (EC 2.7.7.18)
b0639 (nadD) N.D.
NAD(+) synthase (glutamine-hydrolyzing):
nicotinate adenine dinucleotide + ATP + L-glutamine + H2O→NAD+ + AMP + L-glutamate + diphosphate + H+ (EC 6.3.5.1)
No genes
NAD+ + a [histone]-N6-acetyl-L-lysine + H2O→nicotinamide + 2''-O-acetyl-ADP-ribose + a [histone]-L-lysine (EC 2.3.1.286)
No genes
Nicotinamidase:
nicotinamide + H2O→nicotinate + ammonium (EC 3.5.1.19)
b1768 (ydjB) -0.1
nicotinate + ATP + 5-phospho-α-D-ribose 1-diphosphate + H2O→β-nicotinate D-ribonucleotide + ADP + diphosphate + phosphate (EC 6.3.4.21)
b0931 (pncB) -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information