MetaCyc Pathway: Entner-Doudoroff pathway II (non-phosphorylative) in Escherichia coli BW25113

Add experiment(s):


Reactions and Genes D-Ribose (C)
remove
Glucose 1-dehydrogenase (NADP(+)):
D-glucopyranose + NADP+→D-glucono-1,5-lactone + NADPH + H+ (EC 1.1.1.119; 1.1.1.360)
No genes
Gluconolactonase:
D-glucono-1,5-lactone + H2O→D-gluconate + H+ (spontaneous) (EC 3.1.1.17)
No genes
D-gluconate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.140; 4.2.1.39)
No genes
2-dehydro-3-deoxy-D-gluconate→D-glyceraldehyde + pyruvate (EC 4.1.2.51)
b0268 (yagE) -0.2
D-glyceraldehyde + an oxidized electron carrier + H2O→D-glycerate + a reduced two electron carrier + H+ (EC 1.2.99.8)
No genes
D-glycerate + ATP→2-phospho-D-glycerate + ADP + H+ (EC 2.7.1.165)
b0514 (glxK) +0.2
b3124 (garK) -1.6
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
b2779 (eno) N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
b1676 (pykF) -0.5
b1854 (pykA) -1.5
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
b1378 (ydbK) -0.2

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information