MetaCyc Pathway: pyruvate decarboxylation to acetyl CoA I in Pseudomonas putida KT2440

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Reactions and Genes 3-Methyl-2-Oxobutanoic Acid (C)
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a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+→a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (EC 1.2.1.104; 1.8.1.4)
PP_4187 N.D.
PP_4404 -3.7
PP_5366 -0.1
a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + pyruvate + H+→a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2 (EC 1.2.1.104; 1.2.4.1)
PP_0339 -2.8
PP_0554 -0.1
PP_0555 -0.1
a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + coenzyme A→a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + acetyl-CoA (EC 1.2.1.104; 2.3.1.12)
PP_0338 N.D.
PP_0553 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information