MetaCyc Pathway: acrylate degradation I in Pseudomonas putida KT2440

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Reactions and Genes 3-Methyl-2-Oxobutanoic Acid (C)
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acrylate + coenzyme A + H+→acryloyl-CoA + H2O
No genes
acryloyl-CoA + H2O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)
PP_2217 -5.5
3-hydroxyisobutyryl-CoA hydrolase:
3-hydroxypropanoyl-CoA + H2O→3-hydroxypropanoate + coenzyme A + H+ (EC 3.1.2.4)
PP_3491 -4.5
3-hydroxypropionate dehydrogenase:
3-hydroxypropanoate + NAD+→3-oxopropanoate + NADH + H+ (EC 1.1.1.59)
No genes
Malonate-semialdehyde dehydrogenase (acetylating):
3-oxopropanoate + coenzyme A + NAD(P)+→acetyl-CoA + CO2 + NAD(P)H (EC 1.2.1.18)
PP_0597 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information