MetaCyc Pathway: mixed acid fermentation in Pectobacterium carotovorum WPP14

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Reactions and Genes Tuber-Atlantic
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Phosphoenolpyruvate carboxylase (in reverse):
phosphoenolpyruvate + hydrogen carbonate→oxaloacetate + phosphate (EC 4.1.1.31)
HER17_RS20655 -0.1
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
HER17_RS08960 -2.1
HER17_RS11790 -0.4
D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(R)-lactate + NAD+ (EC 1.1.1.28)
HER17_RS09630 +0.2
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
HER17_RS11730 +0.3
HER17_RS13490 -1.5
HER17_RS14120 -0.0
HER17_RS18390 +0.6
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
HER17_RS03410 +0.1
HER17_RS05760 -0.6
HER17_RS12305 -2.2
HER17_RS12310 -2.6
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
HER17_RS11030 -0.0
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
HER17_RS01620 +0.2
HER17_RS14955 -0.1
formate + H+→CO2 + H2
HER17_RS14205 +0.0
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
HER17_RS10755 -0.2
HER17_RS17120 +0.1
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
HER17_RS07080 -1.4
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
HER17_RS07085 N.D.
HER17_RS11770 +0.0
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
HER17_RS03360 N.D.
HER17_RS09315 -0.0
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
HER17_RS02485 +0.2
HER17_RS03445 +0.1
HER17_RS06255 +0.6
HER17_RS11030 -0.0
HER17_RS12790 +0.4
HER17_RS13680 -0.1
HER17_RS17865 +0.4
Succinate dehydrogenase (ubiquinone):
fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
HER17_RS02375 -0.8
HER17_RS02380 -1.3
HER17_RS02385 -0.7
HER17_RS02390 -0.7
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
HER17_RS03360 N.D.
HER17_RS09315 -0.0
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→CO2 + 2-oxoglutarate + NADPH (EC 1.1.1.42)
HER17_RS11610 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information