MetaCyc Pathway: toxoflavin biosynthesis in Escherichia coli BW25113

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Reactions and Genes 2-nitrobenzenesulfonyl fluoride
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GTP cyclohydrolase II:
GTP + 4 H2O→2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate + 3 H+ + 2 phosphate (EC 3.5.4.25)
b0798 (ybiA) +0.0
b1277 (ribA) N.D.
Diaminohydroxyphosphoribosylaminopyrimidine deaminase:
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H+ + H2O→5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonium (EC 3.5.4.26)
b0414 (ribD) N.D.
5-amino-6-(5-phosphoribosylamino)uracil reductase (in reverse):
5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+→5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP+ (EC 1.1.1.193)
b0414 (ribD) N.D.
5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O→5-amino-6-(D-ribitylamino)uracil + phosphate (EC 3.1.3.104)
b0844 (b0844) -0.2
b3812 (yigB) +1.2
5-amino-6-(D-ribitylamino)uracil + glycine→1,6-didemethyltoxoflavin
No genes
1,6-didemethyltoxoflavin + S-adenosyl-L-methionine→reumycin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.349)
No genes
reumycin + S-adenosyl-L-methionine→toxoflavin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.349)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information