MetaCyc Pathway: superpathway of heme b biosynthesis from glycine in Escherichia coli BW25113

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5-aminolevulinate synthase:
glycine + H+ + succinyl-CoA→5-aminolevulinate + CO2 + coenzyme A (EC 2.3.1.37)
No genes
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
b0369 (hemB) N.D.
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
b3805 (hemC) N.D.
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
b3804 (hemD) N.D.
Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
b3997 (hemE) N.D.
Coproporphyrinogen oxidase:
coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
b2436 (hemF) -0.2
Protoporphyrinogen oxidase:
protoporphyrinogen IX + 3 dioxygen→protoporphyrin IX + 3 hydrogen peroxide (EC 1.3.3.4)
b3850 (hemG) N.D.
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
b0475 (hemH) N.D.
b1019 (ycdB) -0.1
b2431 (b2431) -2.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information