MetaCyc Pathway: ketogenesis in Pseudomonas putida KT2440

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Reactions and Genes benzoic (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
PP_0582 +0.0
PP_1377 -6.6
PP_2051 +0.1
PP_2137 -0.5
PP_2215 +0.2
PP_3280 -0.3
PP_3355 -0.1
PP_3754 +0.3
PP_4636 -0.1
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
PP_3393 -0.1
PP_3394 -0.0
PP_3540 N.D.
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
PP_2784 -0.0
PP_3073 -0.5
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information